1. Antifungal Activity of an Antibiotic Lock Solution Containing a Triple Combination of Trimethoprim, EDTA and Ethanol against Candida Species
The implantation and use of prosthetic medical devices has greatly facilitated the management of serious medical and surgical conditions. However, introduction of artificial materials into various body locations can be a route for microorganisms to colonize and form biofilms that protect them from antibiotics and host defenses, leading to persistent infections.
2. Efficacy of a Triple Combination of Trimethoprim, EDTA and 25% Ethanol in the Treatment of Methicillin-Resistant Staphylococcus aureus Catheter Infection
Nosocomial infections due to Staphylococcus aureus have increased recently and their treatment is complicated by the emergence of multi-drug-resistance. Staphylococcal infections are associated with the formation of biofilms on indwelling medical devices, such as indwelling vascular catheters and damaged tissues. Antimicrobial Lock therapy provides a means for delivering high concentrations of drug to resistant biofilms coating catheters. B-Lock™, a triple combination of trimethoprim, EDTA and 25% ethanol is a new product entering clinical development for prevention and treatment of catheter infections.
3. Antifungal Activity of an Antibiotic Lock Solution Containing a Triple Combination of Trimethoprim, EDTA, and Ethanol